Affordable Access

NEW BASE-ALTERED ADENOSINE ANALOGUES: SYNTHESIS AND AFFINITY AT ADENOSINE A1 and A2A RECEPTORS.

Authors
  • Ha, Seung B1
  • Melman, Neli2
  • Jacobson, Kenneth A2
  • Nair, Vasu1
  • 1 Department of Chemistry, The University of Iowa, Iowa City, Iowa 52242, U.S.A.
  • 2 Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892, U.S.A.
Type
Published Article
Journal
Bioorganic & medicinal chemistry letters
Publication Date
Dec 16, 1997
Volume
7
Issue
24
Pages
3085–3090
Identifiers
PMID: 25147430
Source
Medline
License
Unknown

Abstract

N6-Substituted adenosine analogues containing cyclic hydrazines or chiral hydroxy (ar)alkyl groups, designed to interact with the S2 and S3 receptor subregions, have been synthesized and their binding to the adenosine A1 and A2A receptors have been investigated. Examples of both types of compounds were found to exhibit highly selective binding (Ki in low nM range) to the rat A1 receptor.

Report this publication

Statistics

Seen <100 times