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New azasteroidal antifungal antibiotics from Geotrichum flavo-brunneum. II. Isolation and characterization.

Authors
  • Michel, K H
  • Hamill, R L
  • Larsen, S H
  • Williams, R H
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Feb 01, 1975
Volume
28
Issue
2
Pages
102–111
Identifiers
PMID: 1167541
Source
Medline
License
Unknown

Abstract

A novel group of antibiotics, comprising microbiologically-active structurally-related factors A25822A, B, D, H, L, M and N, produced by culturing Geotrichum flavo-brunneum NRRL 3862 under submerged aerobic fermentation conditions was isolated by extraction. The individual factors were separated and purified by chromatography and crystallization. The major factor, A25822B, a 15-aza-24-methylene-D-homocholestadiene is a white crystalline compound, C25H45NO. The antibiotics are highly active against fungi and marginally active against bacteria.

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