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New aspects of renal potassium transport.

Authors
  • Giebisch, Gerhard
  • Hebert, Steven C
  • Wang, Wen-Hui
Type
Published Article
Journal
Pflügers Archiv : European journal of physiology
Publication Date
Jun 01, 2003
Volume
446
Issue
3
Pages
289–297
Identifiers
PMID: 12684792
Source
Medline
License
Unknown

Abstract

The kidney's major role in potassium (K) homeostasis depends on its ability to respond effectively to changes in external K balance and to stabilize the extracellular concentration of K. The correction of deviations from normal plasma K levels and the maintenance of external K balance depend on the intrinsic ability of distal nephron segments to either secrete or reabsorb K. Net K secretion occurs mainly in principal cells while K absorption takes place in intercalated cells. Studies on single tubules and principal and intercalated cells have defined the determinants of K secretion and reabsorption including the electrochemical driving forces, specific carriers, ATPases, and K channels. Recent studies on the properties and molecular identity of renal K channels have also contributed significantly to understanding the renal mechanisms that transport and regulate K excretion.

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