A new antifungal antibiotic, cystargin: fermentation, isolation, and characterization.
- Published Article
The Journal of antibiotics
- Publication Date
Dec 01, 1988
A new sulfur-containing peptide antifungal antibiotic, cystargin, was isolated from the fermentation broth of a new species of genus Kitasatosporia, designated as Kitasatosporia cystarginea. On acid hydrolysis, cystargin (C60H77N19O17S6) gave equimolar glycine, proline, aspartic acid and arginine. By performic acid oxidation, cysteic acid was detected after hydrolysis. It showed a growth inhibitory activity against various phytopathogenic fungi and inhibition of beta-1,3-glucan synthetase from Saccharomyces cerevisiae.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/3209469