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A new antifungal antibiotic, cystargin: fermentation, isolation, and characterization.

Authors
  • Uramoto, M
  • Itoh, Y
  • Sekiguchi, R
  • Shin-ya, K
  • Kusakabe, H
  • Isono, K
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Dec 01, 1988
Volume
41
Issue
12
Pages
1763–1768
Identifiers
PMID: 3209469
Source
Medline
License
Unknown

Abstract

A new sulfur-containing peptide antifungal antibiotic, cystargin, was isolated from the fermentation broth of a new species of genus Kitasatosporia, designated as Kitasatosporia cystarginea. On acid hydrolysis, cystargin (C60H77N19O17S6) gave equimolar glycine, proline, aspartic acid and arginine. By performic acid oxidation, cysteic acid was detected after hydrolysis. It showed a growth inhibitory activity against various phytopathogenic fungi and inhibition of beta-1,3-glucan synthetase from Saccharomyces cerevisiae.

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