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A new antibacterial 3,5-dimethylorsellinic acid-based meroterpene from the marine fungus Aspergillus sp. CSYZ-1.

Authors
  • Cen, Suoyu1
  • Jia, Jia2
  • Ge, Yichao1
  • Ma, Yihan3
  • Li, Xinyang1
  • Wei, Jihua1
  • Bai, Yuefan2
  • Wu, Xiaodan1
  • Song, Jianfeng4
  • Bi, Hongkai5
  • Wu, Bin6
  • 1 Ocean College, Zhejiang University, Zhoushan, Zhejiang 316021, China. , (China)
  • 2 Department of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology & Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211166, China. , (China)
  • 3 Pharmaceutical College, Zhejiang University, Hangzhou 310058, China. , (China)
  • 4 Quzhou Institute for Food and Drug Control, Quzhou 324000, China. , (China)
  • 5 Department of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology & Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address: [email protected] , (China)
  • 6 Ocean College, Zhejiang University, Zhoushan, Zhejiang 316021, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Fitoterapia
Publication Date
Jul 01, 2021
Volume
152
Pages
104908–104908
Identifiers
DOI: 10.1016/j.fitote.2021.104908
PMID: 33892126
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Chemical investigation of the extracts of Aspergillus sp. CSYZ-1 resulted in the identification of compound 1, aspergillactone, a new 3,5-dimethylorsellinic acid-based meroterpenoid, together with four known metabolites (2-5). The structure and relative configuration of 1 were unambiguously determined by nuclear magnetic resonance (NMR), mass spectrometry. The absolute configuration of 1 was defined by quantum chemical TDDFT calculated and the experimental ECD spectra. The possible biosynthetic pathway of compound 1 was also proposed. The new compound exhibited potent antimicrobial activity against Helicobacter pylori and Staphylococcus aureus with MIC values of around 1-4 and 2-16 μg/mL, respectively. Copyright © 2021. Published by Elsevier B.V.

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