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New anti-monocyte chemoattractant protein-1 gene therapy attenuates atherosclerosis in apolipoprotein E-knockout mice.

Authors
  • Ni, W
  • Egashira, K
  • Kitamoto, S
  • Kataoka, C
  • Koyanagi, M
  • Inoue, S
  • Imaizumi, K
  • Akiyama, C
  • Nishida, K I
  • Takeshita, A
Type
Published Article
Journal
Circulation
Publication Date
Apr 24, 2001
Volume
103
Issue
16
Pages
2096–2101
Identifiers
PMID: 11319201
Source
Medline
License
Unknown

Abstract

We conclude that this anti-MCP-1 gene therapy may serve not only to reduce atherogenesis but also to stabilize vulnerable atheromatous plaques. This strategy may be a useful and feasible form of gene therapy against atherosclerosis in humans.

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