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New analogs of acyclovir substituted at the side chain.

Authors
Type
Published Article
Journal
Nucleosides, nucleotides & nucleic acids
Publication Date
Volume
26
Issue
8-9
Pages
917–920
Identifiers
PMID: 18058508
Source
Medline
License
Unknown

Abstract

A series of novel analogs of acyclovir, substituted with an alkyl (methyl, ethyl, n-butyl) or phenyl group at the positions 1', 4', and/or 5', has been obtained in a direct one-pot coupling reaction of guanosine and the respective 1,3-dioxolanes. The new acyclonucleosides were essentially inactive in antiviral (HSV, VV, VSV, HBV) evaluation in vitro.

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