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Neutrophilic leukocyte inclusions in colchicine intoxication.

Authors
  • Powell, H C
  • Wolf, P L
Type
Published Article
Journal
Archives of pathology & laboratory medicine
Publication Date
Mar 01, 1976
Volume
100
Issue
3
Pages
136–138
Identifiers
PMID: 175763
Source
Medline
License
Unknown

Abstract

Large, darkly staining, intracytoplasmic inclusions were observed in the neutrophils of a young woman after suicidal ingestion of colchicine. The polymorphonuclear neutrophils also contained intracytoplasmic and intranuclear vacuoles. Electron microscopy enabled further characterization of these morphologic changes that, although nonspecific, are consistent with certain known toxic effects of colchicine.

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