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Neutrophil serine proteases: specific regulators of inflammation.

Authors
  • Pham, Christine T N
Type
Published Article
Journal
Nat Rev Immunol
Publisher
Nature Publishing Group
Publication Date
Jul 01, 2006
Volume
6
Issue
7
Pages
541–550
Identifiers
PMID: 16799473
Source
Medline
License
Unknown

Abstract

Neutrophils are essential for host defence against invading pathogens. They engulf and degrade microorganisms using an array of weapons that include reactive oxygen species, antimicrobial peptides, and proteases such as cathepsin G, neutrophil elastase and proteinase 3. As discussed in this Review, the generation of mice deficient in these proteases has established a role for these enzymes as intracellular microbicidal agents. However, I focus mainly on emerging data indicating that, after release, these proteases also contribute to the extracellular killing of microorganisms, and regulate non-infectious inflammatory processes by activating specific receptors and modulating the levels of cytokines.

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