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Neutrophil priming by hepatocyte growth factor, a novel cytokine.

Authors
  • W Jiang
  • M C Puntis
  • T Nakamura
  • M B Hallett
Publication Date
Sep 01, 1992
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

We demonstrate here that the recently defined cytokine hepatocyte growth factor (HGF) 'primes' human neutrophils. Recombinant human HGF over the concentration range 0.1-20 ng/ml increased the neutrophil response to f-met-leu-phe by up to 200%, and required only a short preincubation, 10 min producing the maximum effect. Priming was independent of changes in cytosolic-free calcium homeostasis. We conclude that HGF may be a physiologically important cytokine with 'priming' activity for neutrophils.

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