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Neutrophil-infiltrated paw edema induced by mannose-binding Dioclea violacea lectin.

Authors
  • de Alencar, Nylane Maria N1
  • Mota, Mário Rogério L
  • Rodrigues, Natália V F C
  • Martins, Jorge Luiz
  • do Nascimento, Kyria S
  • Assreuy, Ana Maria S
  • Cavada, Benildo S
  • 1 Department of Physiology and Pharmacology, Federal University of Ceará, Cel. Nunes de Melo 1127, 60430-270, Fortaleza, CE, Brazil. , (Brazil)
Type
Published Article
Journal
Pharmacological Reports
Publisher
Elsevier
Publication Date
Jan 01, 2013
Volume
65
Issue
1
Pages
220–225
Identifiers
PMID: 23563042
Source
Medline
License
Unknown

Abstract

DvL induces edema, increase in vascular permeability and neutrophil infiltration. The edematogenic activity involves the lectin mannose-binding sites and is associated with histamine, cytokines and nitric oxide, since it could be treated with meclizine, dexamethasone and L-NAME.

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