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Neutrophil function in the dog: shape change and response to a synthetic tripeptide.

Authors
  • Stickle, J E
  • Kwan, D K
  • Smith, C W
Type
Published Article
Journal
American Journal of Veterinary Research
Publisher
American Veterinary Medical Association
Publication Date
Jan 01, 1985
Volume
46
Issue
1
Pages
225–228
Identifiers
PMID: 3970429
Source
Medline
License
Unknown

Abstract

Isolated dog neutrophils exposed to known chemotactic factors assumed a bipolar configuration in suspension. This response was initiated within 2 minutes with a gradual return to spherical shape. The rate of return to sphere was positively correlated with the dose of stimulant. Dog neutrophils exposed to N-formylmethionyl-leucyl-phenylalanine (fMLP) did not adapt to bipolar conformation and did not bind radiolabeled fMLP. These findings are consistent with other species (pig and cow) that also did not respond to fMLP.

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