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On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little

Authors
  • Santocki, Michal
  • Kolaczkowska, Elzbieta
Type
Published Article
Journal
Cells
Publisher
MDPI AG
Publication Date
Sep 11, 2020
Volume
9
Issue
9
Identifiers
DOI: 10.3390/cells9092079
PMID: 32932841
PMCID: PMC7565917
Source
PubMed Central
Keywords
License
Green

Abstract

Although neutrophil extracellular traps (NETs) were discovered only 16 years ago, they have already taken us from heaven to hell as we learned that apart from beneficial trapping of pathogens, they cause, or contribute to, numerous disorders. The latter is connected to their persistent presence in the blood or tissue, and we hardly know how they are removed in mild pathophysiological conditions and why their removal is impaired in multiple severe pathological conditions. Herein, we bring together all data available up till now on how NETs are cleared—from engaged cells, their phenotypes, to involved enzymes and molecules. Moreover, we hypothesize on why NET removal is challenged in multiple disorders and propose further directions for studies on NET removal as well as possible therapeutic strategies to have them cleared.

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