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Neutrophil depletion delays wound repair in aged mice.

Authors
  • Nishio, Naomi
  • Okawa, Yayoi
  • Sakurai, Hidetoshi
  • Isobe, Ken-ichi
Type
Published Article
Journal
AGE
Publisher
Springer-Verlag
Publication Date
Mar 01, 2008
Volume
30
Issue
1
Pages
11–19
Identifiers
DOI: 10.1007/s11357-007-9043-y
PMID: 19424869
Source
Medline
License
Unknown

Abstract

One of the most important clinical problems in caring for elderly patients is treatment of pressure ulcers. One component of normal wound healing is the generation of an inflammatory reaction, which is characterized by the sequential infiltration of neutrophils, macrophages and lymphocytes. Neutrophils migrate early in the wound healing process. In aged C57BL/6 mice, wound healing is relatively inefficient. We examined the effects of neutrophil numbers on wound healing in both young and aged mice. We found that the depletion of neutrophils by anti-Gr-1 antibody dramatically delayed wound healing in aged mice. The depletion of neutrophils in young mice had less effect on the kinetics of wound healing. Intravenous G-CSF injection increased the migration of neutrophils to the wound site. While the rate of wound repair did not change significantly in young mice following G-CSF injection, it increased significantly in old mice.

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