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Neutrophil Counts to High-Density Lipoprotein Cholesterol Ratio: a Potential Predictor of Prognosis in Acute Ischemic Stroke Patients After Intravenous Thrombolysis.

Authors
  • Chen, Guangyong1
  • Yang, Naiping1, 2
  • Ren, Junli1, 2
  • He, Yibo1, 2
  • Huang, Honghao1, 2
  • Hu, Xueting1, 2
  • Shen, Jiamin1, 2
  • Yang, Chenguang1, 2
  • Zeng, Tian1, 2
  • Hu, Jingyu1, 2
  • Tong, Wangyong1, 2
  • Yang, Dehao3
  • Zhang, Yongyin4
  • 1 Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, Wenzhou, 325000, Zhejiang, China. , (China)
  • 2 School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China. , (China)
  • 3 Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. [email protected] , (China)
  • 4 Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, Wenzhou, 325000, Zhejiang, China. [email protected] , (China)
Type
Published Article
Journal
Neurotoxicity Research
Publisher
Springer-Verlag
Publication Date
Dec 01, 2020
Volume
38
Issue
4
Pages
1001–1009
Identifiers
DOI: 10.1007/s12640-020-00274-1
PMID: 32894456
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Neutrophil counts to high-density lipoprotein cholesterol ratio (NHR) is a relatively new and readily available indicator, and our study aimed to demonstrate its relationship with short-term prognosis after intravenous thrombolysis in acute ischemic stroke (AIS) patients and to make a simple comparison with other prognostic indicators. We compared demographic and laboratory characteristics of AIS patients and healthy controls and grouped AIS patients according to NHR tertiles to contrast 3-month outcomes. Univariate and multivariate regression analyses were carried to further analyze the relationship between NHR and prognosis. Moreover, we compared the accuracy of several factors using receiver-operating characteristic curve. NHR levels of AIS patients were higher than those of healthy controls (p < 0.001). The NHR levels were significantly higher in AIS patients with poor prognosis than those with good prognosis (p = 0.001) and were higher in patients with severe stroke than those with mild stroke (p = 0.011). Multivariate logistic regression analysis indicated that elevated NHR was an independent predictor of poor outcomes (odds ratio = 4.570; 95% CI, 1.841-11.340; p = 0.001). High NHR levels were associated with poor 3-month outcomes after intravenous thrombolysis in AIS patients.

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