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Neuropsychological impairments and their association with obsessive-compulsive symptom severity in obsessive-compulsive disorder.

Authors
  • Abramovitch, Amitai
  • Dar, Reuven
  • Schweiger, Avraham
  • Hermesh, Haggai
Type
Published Article
Journal
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
Publication Date
Jun 01, 2011
Volume
26
Issue
4
Pages
364–376
Identifiers
DOI: 10.1093/arclin/acr022
PMID: 21498424
Source
Medline
License
Unknown

Abstract

Neurobiological research in obsessive-compulsive disorder (OCD) consistently demonstrates an association between abnormal brain activity and symptom severity. Conversely, research addressing the corresponding neuropsychological impairments in OCD and their association with symptom severity has produced inconsistent results. This study reexamines neuropsychological performance and its association with symptom severity in 30 participants with OCD while controlling for confounding variables. We used a computerized neuropsychological battery that was expected to provide more objective and accurate information and minimize examinee-examiner interactions, which may affect performance by reducing anxiety. The OCD group revealed dysfunctions on all neuropsychological domains compared with controls. OCD severity correlated significantly with the composite performance, executive functions, and verbal domain indexes. These results did not change after controlling for depression severity. We suggest that controlling for potential confounding variables and using a computerized battery may have contributed to the association found between obsessive symptoms and neuropsychological impairments. Theoretical implications are discussed.

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