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Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson’s Disease

Authors
  • Choi, Ji-Hyun
  • Lee, Jee-Young
  • Jeon, Beomseok
  • Koh, Seong-Beom
  • Yoon, Won Tae
  • Lee, Ho-Won
  • Kwon, Oh Dae
  • Kim, Jae Woo
  • Kim, Jong-Min
  • Ma, Hyeo-Il
  • Kim, Hee Tae
  • Baik, Jong Sam
  • Cho, Jin Whan
Type
Published Article
Journal
Neurodegenerative Diseases
Publisher
S. Karger AG
Publication Date
May 26, 2020
Volume
19
Issue
5-6
Pages
171–177
Identifiers
DOI: 10.1159/000507447
PMID: 32454490
Source
Karger
Keywords
License
Green
External links

Abstract

Introduction: Impulse control disorder (ICD) in Parkinson’s disease (PD) is a critical nonmotor symptom with personality or neuropsychiatric traits contributing to ICD. Objective: This study aimed to identify predictive traits for persistent or paradoxical aggravation of ICD after dopamine agonist substitution therapy for ICD in PD. Methods: We conducted a case-control study using a database of a multicenter intervention trial for ICD in PD. The poor-outcome group was defined by showing paradoxical increases in ICD behaviors after the substitution of dopamine agonists with levodopa. We analyzed the pre-intervention personality traits associated with the poor outcome and also evaluated the risk traits for refractory ICD using a receiver-operating characteristic (ROC) curve analysis. Results: The poor-outcome group showed higher levels of anger expression (p =0.007) and obsessive-compulsive traits (p =0.009) compared with the good-outcome group at the pre-intervention state. In the ROC curve analysis, the Obsessive-Compulsive Inventory showed the highest area under the curve with 80.0% sensitivity and 74.3% specificity in discriminating against the poor-outcome group. Conclusions: Our results suggest that assessment of obsessive compulsiveness may be useful for predicting the refractoriness of ICD behaviors in planning an interventional treatment for ICD in PD.

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