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Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production.

Authors
  • Goyagi, T1
  • Goto, S
  • Bhardwaj, A
  • Dawson, V L
  • Hurn, P D
  • Kirsch, J R
  • 1 Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Type
Published Article
Journal
Stroke
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
July 2001
Volume
32
Issue
7
Pages
1613–1620
Identifiers
PMID: 11441209
Source
Medline
License
Unknown

Abstract

These data suggest that the mechanism of neuroprotection of PPBP in vivo is through attenuation of nNOS activity and ischemia-evoked NO production. Neuroprotective effects of PPBP are lost when nNOS is not present or is inhibited; therefore, PPBP likely acts upstream from NO generation and its subsequent neurotoxicity.

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