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Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production.

Authors
  • 1
Type
Published Article
Journal
Stroke
1524-4628
Publication Date
Volume
32
Issue
7
Pages
1613–1620
Identifiers
PMID: 11441209
Source
Medline

Abstract

These data suggest that the mechanism of neuroprotection of PPBP in vivo is through attenuation of nNOS activity and ischemia-evoked NO production. Neuroprotective effects of PPBP are lost when nNOS is not present or is inhibited; therefore, PPBP likely acts upstream from NO generation and its subsequent neurotoxicity.

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