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A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

  • Tyzack, Giulia E.1, 2
  • Hall, Claire E.2
  • Sibley, Christopher R.3
  • Cymes, Tomasz1
  • Forostyak, Serhiy4
  • Carlino, Giulia2
  • Meyer, Ione F.5
  • Schiavo, Giampietro5, 6
  • Zhang, Su-Chun7
  • Gibbons, George M.1
  • Newcombe, Jia8
  • Patani, Rickie2, 9
  • Lakatos, András1, 10
  • 1 University of Cambridge, E.D. Adrian Building, John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK , Cambridge (United Kingdom)
  • 2 University College London, Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK , London (United Kingdom)
  • 3 Burlington Danes Building Du Cane Road, Division of Brain Sciences, Imperial College London, London, W12 0NN, UK , London (United Kingdom)
  • 4 Department of Neuroscience, Institute of Experimental Medicine ASCR and Charles University in Prague, Videnská 1083, Prague 4, 142 20, Czech Republic , Prague 4 (Czechia)
  • 5 UCL Institute of Neurology, University College London, Sobell Department of Motor Neuroscience & Movement Disorders, London, WC1N 3BG, UK , London (United Kingdom)
  • 6 University College London, UK Dementia Research Institute at UCL, UCL Institute of Neurology, London, WC1N 3BG, UK , London (United Kingdom)
  • 7 University of Wisconsin, Waisman Center, 1500 Highland Avenue, Madison, WI, 53705, USA , Madison (United States)
  • 8 University College London, Department of Neuroinflammation, UCL Institute of Neurology, London, WC1N 1PJ, UK , London (United Kingdom)
  • 9 The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK , London (United Kingdom)
  • 10 Cambridge University Hospitals, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0QQ, UK , Cambridge (United Kingdom)
Published Article
Nature Communications
Springer Nature
Publication Date
Oct 27, 2017
DOI: 10.1038/s41467-017-01283-z
Springer Nature


Astrocytes can have protective or detrimental effects on neurons during injury, but the molecular mechanisms that determine these different states are unresolved. Here the authors identify a pathway via neuronal EphB1 that induces neuroprotective signalling in astrocytes through ephrin-B1 mediated STAT3 activation, which is impaired in models of amyotrophic lateral sclerosis.

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