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A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

Authors
  • Tyzack, Giulia E.1, 2
  • Hall, Claire E.2
  • Sibley, Christopher R.3
  • Cymes, Tomasz1
  • Forostyak, Serhiy4
  • Carlino, Giulia2
  • Meyer, Ione F.5
  • Schiavo, Giampietro5, 6
  • Zhang, Su-Chun7
  • Gibbons, George M.1
  • Newcombe, Jia8
  • Patani, Rickie2, 9
  • Lakatos, András1, 10
  • 1 University of Cambridge, E.D. Adrian Building, John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK , Cambridge (United Kingdom)
  • 2 University College London, Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK , London (United Kingdom)
  • 3 Burlington Danes Building Du Cane Road, Division of Brain Sciences, Imperial College London, London, W12 0NN, UK , London (United Kingdom)
  • 4 Department of Neuroscience, Institute of Experimental Medicine ASCR and Charles University in Prague, Videnská 1083, Prague 4, 142 20, Czech Republic , Prague 4 (Czechia)
  • 5 UCL Institute of Neurology, University College London, Sobell Department of Motor Neuroscience & Movement Disorders, London, WC1N 3BG, UK , London (United Kingdom)
  • 6 University College London, UK Dementia Research Institute at UCL, UCL Institute of Neurology, London, WC1N 3BG, UK , London (United Kingdom)
  • 7 University of Wisconsin, Waisman Center, 1500 Highland Avenue, Madison, WI, 53705, USA , Madison (United States)
  • 8 University College London, Department of Neuroinflammation, UCL Institute of Neurology, London, WC1N 1PJ, UK , London (United Kingdom)
  • 9 The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK , London (United Kingdom)
  • 10 Cambridge University Hospitals, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0QQ, UK , Cambridge (United Kingdom)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Oct 27, 2017
Volume
8
Issue
1
Identifiers
DOI: 10.1038/s41467-017-01283-z
Source
Springer Nature
License
Green

Abstract

Astrocytes can have protective or detrimental effects on neurons during injury, but the molecular mechanisms that determine these different states are unresolved. Here the authors identify a pathway via neuronal EphB1 that induces neuroprotective signalling in astrocytes through ephrin-B1 mediated STAT3 activation, which is impaired in models of amyotrophic lateral sclerosis.

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