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Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity

Authors
  • Liu, Chang1, 2
  • Somasundaram, Ashwin2, 1
  • Manne, Sasikanth3
  • Gocher, Angela M.1, 2
  • Szymczak-Workman, Andrea L.1
  • Vignali, Kate M.1, 2
  • Scott, Ellen N.1, 2, 1
  • Normolle, Daniel P.2
  • John Wherry, E.3
  • Lipson, Evan J.4
  • Ferris, Robert L.2, 1, 2
  • Bruno, Tullia C.1, 2, 2
  • Workman, Creg J.1, 2
  • Vignali, Dario A. A.1, 2, 2
  • 1 University of Pittsburgh School of Medicine, Pittsburgh, PA, USA , Pittsburgh (United States)
  • 2 UPMC Hillman Cancer Center, Pittsburgh, PA, USA , Pittsburgh (United States)
  • 3 University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA , Philadelphia (United States)
  • 4 Sidney Kimmel Comprehensive Cancer Center (SKCCC), and Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA , Baltimore (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jul 13, 2020
Volume
21
Issue
9
Pages
1010–1021
Identifiers
DOI: 10.1038/s41590-020-0733-2
Source
Springer Nature
License
Yellow

Abstract

T cell exhaustion limits antitumor immune responses. Vignali and colleagues identify neuropilin-1 as a novel immune checkpoint that cell-intrinsically operates to limit memory cell formation and can be targeted to enhance antitumor responses.

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