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Neurophysiological Correlate of Emotion Regulation by Cognitive Reappraisal and Its Association With Psychotic Symptoms in Early Psychosis.

Authors
  • Kim, Minah1, 2
  • Hwang, Wu Jeong3
  • Park, Jihye3
  • Kim, Taekwan3
  • Oh, Sanghoon1, 2
  • Kwon, Jun Soo1, 2, 3, 4
  • 1 Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. , (North Korea)
  • 2 Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. , (North Korea)
  • 3 Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea. , (North Korea)
  • 4 Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. , (North Korea)
Type
Published Article
Journal
Schizophrenia bulletin
Publication Date
Jan 23, 2021
Volume
47
Issue
1
Pages
87–96
Identifiers
DOI: 10.1093/schbul/sbaa080
PMID: 32609340
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Emotion dysregulation is crucial to both poor social functioning and psychotic symptom formation in patients with schizophrenia. The efficient use of emotion regulation strategies, such as cognitive reappraisal, has been less frequently observed in the early phases of psychotic disorder. It is unknown whether neurophysiological responses related to emotion regulation by cognitive reappraisal are altered in early psychosis. Fifty-four patients with first-episode psychosis (FEP), 34 subjects at clinical high risk (CHR) for psychosis, and 30 healthy controls (HCs) participated in event-related potential recordings during a validated emotion regulation paradigm to measure the effect of cognitive reappraisal on emotion regulation. Late positive potentials (LPPs), which reflect emotional arousal, were compared across the groups and the 3 conditions (negative, cognitive reappraisal, and neutral). The relationship among LPP modulation by cognitive reappraisal and social/role functioning and severity of psychotic symptoms was investigated in the early psychosis group. The FEP and CHR participants showed comparably larger LPP amplitudes in the negative and cognitive reappraisal conditions than in the neutral condition, whereas the HCs presented larger LPPs in the negative condition than in the cognitive reappraisal and neutral conditions. LPP modulation by cognitive reappraisal was negatively correlated with positive symptom severity in the FEP patients and with disorganization severity in the CHR subjects. Inefficient use of cognitive reappraisal may be related to the impaired emotion regulation and psychotic symptoms from the very beginning of psychotic disorder. This study provides the first neurophysiological evidence regarding current concepts of emotion regulation in early psychosis. © The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: [email protected]

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