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Neuropeptides related to [Arg8]vasopressin facilitates social recognition in rats.

Authors
  • Popik, P1
  • Wolterink, G
  • De Brabander, H
  • van Ree, J M
  • 1 Department of Pharmacology, Rudolf Magnus Institute, Medical Faculty University of Utrecht, The Netherlands. , (Netherlands)
Type
Published Article
Journal
Physiology & Behavior
Publisher
Elsevier
Publication Date
Jun 01, 1991
Volume
49
Issue
6
Pages
1031–1035
Identifiers
PMID: 1896485
Source
Medline
License
Unknown

Abstract

The decrease of social investigations of adult rats during a second encounter session with the same juvenile was used as an index of social recognition or memory. Social recognition was present when the interexposure interval was 15 or 30 min, but not when this interval lasted 60 or 120 min. Animals treated with desglycinamide[Arg8]vasopressin (DGAVP) (6.0 micrograms.kg-1, SC) or [pGlu4,Cyt6]AVP-(4-8) (AVP-(4-8] (1.0 microgram.kg-1, SC), immediately after the first encounter, recognized the same juveniles still after 120 min, suggesting a facilitatory effect of these peptides on social recognition and that this effect of vasopressin is dissociated from the classical endocrine effects of this hormone. The decrease of social investigating behavior, in both placebo- and DGAVP-treated rats, was completely due to a decrease in anogenital exploration, indicating that the social recognition in rats is presumably based on odor cues from the anogenital part of the body.

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