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Neurons in the brain of fetal rhesus monkeys accumulate 3H-testosterone or its metabolites.

Authors
Type
Published Article
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
38
Issue
18
Pages
1673–1677
Identifiers
PMID: 3702596
Source
Medline

Abstract

Autoradiography was used to map sites in the primate brain at which testosterone may have sexual differentiating actions on brain function and behavior during fetal development. Two female rhesus monkey fetuses were injected in utero on days 112 and 114 of gestation respectively with 3H-testosterone, and were killed 30 and 60 minutes later. Thaw-mount autoradiography of the brains revealed the accumulation of radioactivity, representing 3H-testosterone or its metabolites, in neurons of the medial preoptic-anterior hypothalamic area, bed nucleus (n.) of the stria terminalis, ventromedial hypothalamic n., and corticomedial amygdala. Thus, it appears that steroid receptors are present in a circumscribed system in the brain of the primate fetus at this stage of development.

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