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Neuronal nitric oxide synthase and renin stimulation by sodium deprivation are dependent on the renal nerves.

Authors
Type
Published Article
Journal
Journal of Hypertension
0263-6352
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Volume
20
Issue
10
Pages
2039–2045
Identifiers
PMID: 12359983
Source
Medline
License
Unknown

Abstract

The renal nerves mediate the increase of renin and nNOS mRNA during sodium restriction, while the suppression of nNOS and renin gene expression during a sodium load is independent of the presence of the renal nerves. The parallel changes in renin and nNOS mRNA during different sodium intakes suggest that nNOS can be part of the complex, and still largely unclarified, macula densa mechanism of renin regulation.

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