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Neuronal misconnections and psychiatric disorder. Is there a link?

Authors
  • Goodman, R
Type
Published Article
Journal
The British journal of psychiatry : the journal of mental science
Publication Date
Mar 01, 1989
Volume
154
Pages
292–299
Identifiers
PMID: 2688774
Source
Medline
License
Unknown

Abstract

Brain damage can induce anomalous neuronal connections in experimental animals, which can sometimes result in maladaptive behaviour, particularly when damage occurs early in development. Anomalous patterns of neuronal connection can also arise from genetic disorders. In humans, neuronal misconnections could be involved in a variety of psychiatric disorders. For example, they may account for the link between hyperkinesis and childhood hemiplegia, and for the link between schizophrenia and 'alien tissue' lesions of the temporal lobes. Predictions from misconnection hypotheses can potentially be tested in neuropathological, neurophysiological, and clinical studies.

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