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Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception

Authors
  • Gendron, Christi M.
  • Chakraborty, Tuhin S.
  • Chung, Brian Y.
  • Harvanek, Zachary M.
  • Holme, Kristina J.
  • Johnson, Jacob C.
  • Lyu, Yang
  • Munneke, Allyson S.
  • Pletcher, Scott D.
Type
Published Article
Journal
Annual Review of Physiology
Publisher
Annual Reviews
Publication Date
Feb 10, 2020
Volume
82
Pages
227–249
Identifiers
DOI: 10.1146/annurev-physiol-021119-034440
Source
Annual Reviews
Keywords
License
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Abstract

Sensory neurons provide organisms with data about the world in which they live, for the purpose of successfully exploiting their environment. The consequences of sensory perception are not simply limited to decision-making behaviors; evidence suggests that sensory perception directly influences physiology and aging, a phenomenon that has been observed in animals across taxa. Therefore, understanding the neural mechanisms by which sensory input influences aging may uncover novel therapeutic targets for aging-related physiologies. In this review, we examine different perceptive experiences that have been most clearly linked to aging or age-related disease: food perception, social perception, time perception, and threat perception. For each, the sensory cues, receptors, and/or pathways that influence aging as well as the individual or groups of neurons involved, if known, are discussed. We conclude with general thoughts about the potential impact of this line of research on human health and aging.

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