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Neuronal intermediate filaments: new progress on an old subject.

Authors
  • Xu, Z
  • Dong, D L
  • Cleveland, D W
Type
Published Article
Journal
Current Opinion in Neurobiology
Publisher
Elsevier
Publication Date
Oct 01, 1994
Volume
4
Issue
5
Pages
655–661
Identifiers
PMID: 7849521
Source
Medline
License
Unknown

Abstract

Neurofilaments (NFs) are the major intermediate filaments in most mature neurons. Genetic approaches have now proven that NFs are an essential determinant for radial growth of axons. NF phosphorylation most probably plays an important role in this function. Further, forced over-expression of NF subunits in transgenic mice yields NF misaccumulation in motor neurons and, subsequently, causes motor neuron dysfunction. This has important implications for human motor neuron diseases because similar accumulations are nearly universally found in the early stages of many motor neuron disorders.

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