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Neuronal correlates of goal-based motor selection in the prefrontal cortex.

Authors
  • Matsumoto, Kenji
  • Suzuki, Wataru
  • Tanaka, Keiji
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Jul 11, 2003
Volume
301
Issue
5630
Pages
229–232
Identifiers
PMID: 12855813
Source
Medline
License
Unknown

Abstract

Choosing an action that leads to a desired goal requires an understanding of the linkages between actions and their outcomes. We investigated neural mechanisms of such goal-based action selection. We trained monkeys on a task in which the relation between visual cues, action types, and reward conditions changed regularly, such that the monkeys selected their actions based on anticipated reward conditions. A significant number of neurons in the medial prefrontal cortex were activated, after cue presentation and before motor execution, only by particular action-reward combinations. This prefrontal activity is likely to underlie goal-based action selection.

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