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Neuromuscular hyperexcitability associated with acetylcholine receptor antibodies in a child.

Authors
  • Oskarsson, Björn
  • Zawadzki, Lucyna
  • Benke, Timothy
  • Quan, Dianna
Type
Published Article
Journal
Journal of Child Neurology
Publisher
SAGE Publications
Publication Date
Jan 01, 2009
Volume
24
Issue
1
Pages
90–92
Identifiers
DOI: 10.1177/0883073808320755
PMID: 18936193
Source
Medline
License
Unknown

Abstract

This report describes the clinical and electrophysiological features of an 8-year-old boy with autoimmune neuromuscular hyperexcitability. He presented with features of lower extremity pain, stiffness, and rippling muscles. The diagnosis was made by electromyography and supported by the presence of an antibody directed against nicotinic acetylcholine receptors. His symptoms responded to immunomodulatory treatment with intravenous immunoglobulin. Response to immunomodulatory therapy has not previously been described in the pediatric population with autoimmune neuromuscular hyperexcitability. This case highlights that this is a treatable condition.

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