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Neurological, visual, and MRI brain scan findings in 87 South African patients with HIV-associated cryptococcal meningoencephalitis.

Authors
  • Loyse, A1
  • Moodley, A2
  • Rich, P3
  • Molloy, S F4
  • Bicanic, T4
  • Bishop, L5
  • Rae, W I D6
  • Bhigjee, A I7
  • Loubser, N D2
  • Michowicz, A J5
  • Wilson, D5
  • Harrison, T S4
  • 1 Department of Medicine, Edendale Hospital, Pietermaritzburg, South Africa; Cryptococcal Meningitis Group, Research Centre for Infection and Immunity, Division of Clinical Sciences, St. George's University of London, UK. Electronic address: [email protected] , (South Africa)
  • 2 Department of Neurology, Grey's Hospital, Pietermaritzburg, South Africa. , (South Africa)
  • 3 Department of Neuroradiology, St George's Hospital, London, UK.
  • 4 Cryptococcal Meningitis Group, Research Centre for Infection and Immunity, Division of Clinical Sciences, St. George's University of London, UK.
  • 5 Department of Medicine, Edendale Hospital, Pietermaritzburg, South Africa. , (South Africa)
  • 6 Department of Medical Physics, University of the Free State, South Africa. , (South Africa)
  • 7 Department of Neurology, University of KwaZulu Natal, South Africa. , (South Africa)
Type
Published Article
Journal
The Journal of infection
Publication Date
June 2015
Volume
70
Issue
6
Pages
668–675
Identifiers
DOI: 10.1016/j.jinf.2014.10.007
PMID: 25444972
Source
Medline
Keywords
License
Unknown

Abstract

The majority of patients had MRI brain scan abnormalities presumed secondary to CM. Dilated Virchow Robin spaces were the commonest neuroradiological lesion. Visual loss was associated with the degree of cerebral involvement as reflected by the presence of MRI abnormalities. Blindness was associated with the presence of raised ICP. Initial generalised brain swelling does not appear to be common, but further studies with paired scans are needed.

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