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Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid

Authors
  • Heming, Michael1
  • Li, Xiaolin1
  • Räuber, Saskia1
  • Mausberg, Anne K.2
  • Börsch, Anna-Lena1
  • Hartlehnert, Maike1
  • Singhal, Arpita3
  • Lu, I-Na1
  • Fleischer, Michael2
  • Szepanowski, Fabian2
  • Witzke, Oliver4
  • Brenner, Thorsten5
  • Dittmer, Ulf6
  • Yosef, Nir3, 7, 8
  • Kleinschnitz, Christoph2
  • Wiendl, Heinz1
  • Stettner, Mark2
  • Meyer zu Hörste, Gerd1
  • 1 Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany
  • 2 Department of Neurology, University Hospital Essen, Essen, Germany
  • 3 Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA
  • 4 Department of Infectious Diseases, West German Centre of Infectious Diseases, University Duisburg-Essen, Germany
  • 5 Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany
  • 6 Institute for Virology, University Hospital Essen, Germany
  • 7 Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA
  • 8 Chan Zuckerberg Biohub, San Francisco, CA, USA
Type
Published Article
Journal
Immunity
Publication Date
Dec 23, 2020
Volume
54
Issue
1
Pages
164–175
Identifiers
DOI: 10.1016/j.immuni.2020.12.011
PMID: 33382973
PMCID: PMC7831653
Source
PubMed Central
Keywords
License
Unknown

Abstract

Neurological manifestations associated with COVID-19 (Neuro-COVID) are recognized but under-studied. Using single-cell transcriptomics, Heming et al. identify expansion of dedifferentiated monocytes and exhausted CD4+ T cells in the cerebral spinal fluid of Neuro-COVID patients. This work provides a basis for improved understanding of the neurological sequelae associated with COVID-19.

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