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Neurologic Complications of Cancer Therapies

Authors
  • Lee, Eudocia Q.1
  • 1 Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA , Boston (United States)
Type
Published Article
Journal
Current Neurology and Neuroscience Reports
Publisher
Springer-Verlag
Publication Date
Nov 24, 2021
Volume
21
Issue
12
Identifiers
DOI: 10.1007/s11910-021-01151-w
Source
Springer Nature
Keywords
Disciplines
  • Topical Collection on Neuro-Oncology
License
Yellow

Abstract

Purpose of ReviewTo review the neurologic complications of systemic anti-cancer therapies and radiation therapy.Recent FindingsAlthough many of the newer systemic therapies have more favorable side effect profiles than traditional cytotoxic chemotherapy, neurotoxicity has been seen with some of newer targeted therapies, immunotherapy, and T cell engaging therapies, including CAR-T therapy. The most recent advances in radiation-induced neurotoxicity have focused on the prevention and the management of cognitive dysfunction, a known long-term complication of brain irradiation.SummaryCancer therapies can damage both the central and the peripheral nervous systems, and the damage may not always be reversible. Neurologists and oncologists must be aware of the neurotoxicities associated with newer treatments, particularly CAR-T therapy and immunotherapy. Early recognition and appropriate management can help minimize neurologic injury.

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