We have reported the case of a 65-year-old woman treated with neuroleptics because of organic delusive disturbances. She was treated for about one month with risperidone (Rispolept) and perazine (Pernazinum). Around ten days before the patient was admitted to this ward, the following had been observed: rise in temperature up to 40 degrees C, progressive weakness and blood pressure (RR) fluctuationis. Despite the applied treatment, the patient died during the fourth of hospitalization on this ward. The diagnosis of neuroleptic malignant syndrome was made on the basis of the clinical picture accomplished whole of biochemical, figurative tests as well as on the conducted differential diagnostics.