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Neuroinflammation During RNA Viral Infections

Authors
  • Klein, Robyn S.
  • Garber, Charise
  • Funk, Kristen E.
  • Salimi, Hamid
  • Soung, Allison
  • Kanmogne, Marlene
  • Manivasagam, Sindhu
  • Agner, Shannon
  • Cain, Matthew
Type
Published Article
Journal
Annual Review of Immunology
Publisher
Annual Reviews
Publication Date
Apr 26, 2019
Volume
37
Pages
73–95
Identifiers
DOI: 10.1146/annurev-immunol-042718-041417
Source
Annual Reviews
Keywords
License
Yellow

Abstract

Neurotropic RNA viruses continue to emerge and are increasingly linked to diseases of the central nervous system (CNS) despite viral clearance. Indeed, the overall mortality of viral encephalitis in immunocompetent individuals is low, suggesting efficient mechanisms of virologic control within the CNS. Both immune and neural cells participate in this process, which requires extensive innate immune signaling between resident and infiltrating cells, including microglia and monocytes, that regulate the effector functions of antiviral T and B cells as they gain access to CNS compartments. While these interactions promote viral clearance via mainly neuroprotective mechanisms, they may also promote neuropathology and, in some cases, induce persistent alterations in CNS physiology and function that manifest as neurologic and psychiatric diseases. This review discusses mechanisms of RNA virus clearance and neurotoxicity during viral encephalitis with a focus on the cytokines essential for immune and neural cell inflammatory responses and interactions. Understanding neuroimmune communications in the setting of viral infections is essential for the development of treatments that augment neuroprotective processes while limiting ongoing immunopathological processes that cause ongoing CNS disease.

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