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Neuroglial patterns are shared by cerebella from prion and prion-like disorder affected patients.

Authors
  • Garcés, Moisés1
  • Guijarro, M Isabel1
  • Vargas, Antonia1
  • Badiola, Juan J1
  • Monzón, Marta2
  • 1 Research Centre for Encephalopathies and Transmissible Emerging Diseases, Institute for Health Research Aragón (IIS), University of Zaragoza, Spain. , (Spain)
  • 2 Research Centre for Encephalopathies and Transmissible Emerging Diseases, Institute for Health Research Aragón (IIS), University of Zaragoza, Spain. Electronic address: [email protected] , (Spain)
Type
Published Article
Journal
Mechanisms of ageing and development
Publication Date
Dec 01, 2019
Volume
184
Pages
111176–111176
Identifiers
DOI: 10.1016/j.mad.2019.111176
PMID: 31689427
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are considered prion-like disorders because they are all proteinopathies in which aberrant proteins spread throughout the brain during disease progression. The overall aim of this study is to determine how glial cells are commonly involved in the neurodegeneration progress observed in all these pathologies. The suggestion that they are cell types in which prion and prion-like disorders have common behaviour is the hypothesis on which this study is based. Morphological and distribution differences in astroglial and microglial cells in the cerebellum from prion and prion-like disease-affected patients were assessed here by histopathological and immunochemical tools. To our knowledge, this is the first study to focus on the comparative assessment of glial profiles in these human brains. Activated microglial population was demonstrated in both, prion and prion-like disorders, although in higher extent in the first. In astroglial activation, specific patterns of alterations suggesting both degenerative and potentially neuroprotective or restorative stem cell response, were shown to be alternatively shared by cerebella from all disorders studied. Neuro-protective strategies for these disabling disorders are particularly desirable. Copyright © 2019 Elsevier B.V. All rights reserved.

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