Affordable Access

Neurofilaments and neurological disease.

Authors
  • 1
Type
Published Article
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
Publication Date
Volume
25
Issue
4
Pages
346–355
Identifiers
PMID: 12655642
Source
Medline

Abstract

Neurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by post-translational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells. Neurofilament accumulations are seen in several neurological diseases and neurofilament mutations have now been associated with Charcot-Marie-Tooth disease, Parkinson's disease and amyotrophic lateral sclerosis. In this review, we discuss the structure, normal function and molecular pathology of neurofilaments.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments