Affordable Access

Neurofilaments and neurological disease.

Authors
  • Al-Chalabi, Ammar1
  • Miller, Christopher C J
  • 1 Departments of Neuroscience and Neurology, Institute of Psychiatry, King's College London, London SE5 8AF, UK. [email protected]
Type
Published Article
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
Publication Date
April 2003
Volume
25
Issue
4
Pages
346–355
Identifiers
PMID: 12655642
Source
Medline
License
Unknown

Abstract

Neurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by post-translational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells. Neurofilament accumulations are seen in several neurological diseases and neurofilament mutations have now been associated with Charcot-Marie-Tooth disease, Parkinson's disease and amyotrophic lateral sclerosis. In this review, we discuss the structure, normal function and molecular pathology of neurofilaments.

Report this publication

Statistics

Seen <100 times