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Neurofibromatosis and childhood leukemia.

Authors
  • Bader, J L
  • Miller, R W
Type
Published Article
Journal
The Journal of Pediatrics
Publisher
Elsevier
Publication Date
Jun 01, 1978
Volume
92
Issue
6
Pages
925–929
Identifiers
PMID: 96239
Source
Medline
License
Unknown

Abstract

Twelve new cases of childhood leukemia and neurofibromatosis were ascertained and evaluated in conjunction with 17 previously well-documented cases. The ratio of ALL:nonlymphocytic leukemia was 9:20, markedly different from the 4:1 ratio in children without NF. Rarer subtypes predominated: 8 CML and 8 AMML. The peculiar distribution of leukemia by cell type and the number of cases observed in the United States indicate that the risk of childhood leukemia in NF is increased. Two possible variants were noted: NF with "transient leukemia," and multiple skin xanthomas with nonlymphocytic leukemia.

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