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Neuroendocrine tumor (NET) of the vagina in the light of WHO 2020 2-tiered grading system: clinicopathological report of the first described case.

Authors
  • Inzani, Frediano1
  • Santoro, Angela1
  • Angelico, Giuseppe1
  • Mastrosimini, Maria Gaia2
  • Masciullo, Valeria3
  • Salutari, Vanda4
  • Zannoni, Gian Franco5, 6, 7
  • 1 Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Unità di Gineco-patologia e Patologia Mammaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. , (Italy)
  • 2 Department of Diagnostics and Public Health, G.B. Rossi University Hospital, Verona, Italy. , (Italy)
  • 3 Division of Gynecology, Dipartimento Scienze della Salute della donna e del bambino e di Sanità pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. , (Italy)
  • 4 Gynecologic Oncology Unit, Department of Woman, Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy. , (Italy)
  • 5 Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Unità di Gineco-patologia e Patologia Mammaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. [email protected] , (Italy)
  • 6 Istituto di Anatomia Patologica, Università Cattolica del Sacro Cuore, Rome, Italy. [email protected] , (Italy)
  • 7 Department of Woman and Child Health, UCSC and Fondazione Policlinico Gemelli, Rome, Italy. [email protected] , (Italy)
Type
Published Article
Journal
Virchows Archiv
Publisher
Springer Berlin Heidelberg
Publication Date
Mar 01, 2022
Volume
480
Issue
3
Pages
687–691
Identifiers
DOI: 10.1007/s00428-021-03078-6
PMID: 33881615
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Up to now, a vaginal well-differentiated neuroendocrine tumor (NET) has never been well described in the literature. A 2-cm vaginal nodule morphologically revealed a proliferation of mild to moderately atypical eosinophilic epithelioid cells, without tumor cell necrosis. Immunohistochemistry (IHC) showed positivity for CK (AE1/AE3), chromogranin A, and synaptophysin, focal positivity for CDX2, and negativity for PAX8 and TTF1. Metastatic origin was excluded by imaging and the morphological context with benign mucinous glands as present in the surgical resection specimen. Considering mitotic index and Mib1/Ki67 (8 mitoses/2 mm2; >20%), the case was diagnosed as vaginal NET G2 in the light of the WHO 2020 grading system for the gynecologic neuroendocrine neoplasms (NENs). Ranges of Mib1-Ki67 are not yet standardized. Currently, mitotic index and tumor cell necrosis were taken into consideration for the grading system. Gynecologic NENs still represent a diagnostic challenge. A clinico-radiologic workup and an appropriate diagnostic path ruling out the metastatic nature are mandatory to achieve the diagnosis. © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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