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Neuro-dermatological association between psoriasis and depression: an immune-mediated inflammatory process validating skin-brain axis theory.

Authors
  • Maqbool, Shahzaib1
  • Ihtesham, Arham1
  • Langove, Muhammad Nadeem1
  • Jamal, Sara2
  • Jamal, Tabdar3
  • Safian, Hafiz Abu1
  • 1 Department of Medicine, Rawalpindi Medical University, Pakistan. , (Pakistan)
  • 2 Department of Haematology, Resident Haematology atomic energy Islamabad, Pakistan. , (Pakistan)
  • 3 Department of Radiology, Resident Radiology Kahuta Research Laboratory (KRL) hospital, Pakistan. , (Pakistan)
Type
Published Article
Journal
AIMS neuroscience
Publication Date
Jan 01, 2021
Volume
8
Issue
3
Pages
340–354
Identifiers
DOI: 10.3934/Neuroscience.2021018
PMID: 34183985
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Our study's motive was to recognize various immune-mediated inflammatory processes involved in the pathogenesis of depression and psoriasis and interlink between them based on inflammatory mediators. A careful and comprehensive literature search was done through various databases like PubMed, Google Scholar, and EBSCO. A total of 56 studies were included in our study after careful screening. The immune-mediated inflammatory process was significantly associated with the pathogenesis of both depression and psoriasis. Most of the inflammatory markers involved in Psoriasis (TNF-α, IL-2, IL-6, IL-23, IL-1β, IL-10), and increased serotonin transporters (5-HTT) were also found in the pathogenesis of depression, showing the immune-inflammatory linkage between psoriasis and major depression. Based on immune chemistry, the levels of CD2+, CD4+, CD8+ T-lymphocytes were also found to be raised in both depression and psoriasis, validating their relationship. Hyperactivity of HPA-axis was also found another interlink between them along with reduced melatonin amount. According to various studies, the neuro-dermatological association between psoriasis and depression is significant. Different immune markers involved in the pathogenesis of depression and psoriasis also show the bidirectional association between them. However, this association between psoriasis and depression is positively correlated, but more work is required to answer why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression. © 2021 the Author(s), licensee AIMS Press.

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