Affordable Access

Access to the full text

Neurochemical and molecular mechanisms underlying the retrieval-extinction effect

Authors
  • Cahill, Emma N.
  • Milton, Amy L.
Type
Published Article
Journal
Psychopharmacology
Publisher
Springer Berlin Heidelberg
Publication Date
Jan 17, 2019
Volume
236
Issue
1
Pages
111–132
Identifiers
DOI: 10.1007/s00213-018-5121-3
Source
Springer Nature
Keywords
License
Green

Abstract

Extinction within the reconsolidation window, or ‘retrieval-extinction’, has received much research interest as a possible technique for targeting the reconsolidation of maladaptive memories with a behavioural intervention. However, it remains to be determined whether the retrieval-extinction effect—a long-term reduction in fear behaviour, which appears resistant to spontaneous recovery, renewal and reinstatement—depends specifically on destabilisation of the original memory (the ‘reconsolidation-update’ account) or represents facilitation of an extinction memory (the ‘extinction-facilitation’ account). We propose that comparing the neurotransmitter systems, receptors and intracellular signalling pathways recruited by reconsolidation, extinction and retrieval-extinction will provide a way of distinguishing between these accounts.

Report this publication

Statistics

Seen <100 times