Affordable Access

deepdyve-link
Publisher Website

Neurobiological mechanisms for impulsive-aggression: the role of MAOA.

Authors
  • Dorfman, Hayley M
  • Meyer-Lindenberg, Andreas
  • Buckholtz, Joshua W
Type
Published Article
Journal
Current topics in behavioral neurosciences
Publication Date
Jan 01, 2014
Volume
17
Pages
297–313
Identifiers
DOI: 10.1007/7854_2013_272
PMID: 24470068
Source
Medline
License
Unknown

Abstract

Aggression may be present across a large part of the spectrum of psychopathology, and underlies costly criminal antisocial behaviors. Human aggression is a complex and underspecified construct, confounding scientific discovery. Nevertheless, some biologically tractable subtypes are apparent, and one in particular-impulsive (reactive) aggression-appears to account for many facets of aggression-related dysfunction in psychiatric illness. Impulsive-aggression is significantly heritable, suggesting genetic transmission. However, the specific neurobiological mechanisms that mediate genetic risk for impulsive-aggression remain unclear. Here, we review extant data on the genetics and neurobiology of individual differences in impulsive-aggression, with particular attention to the role of genetic variation in Monoamine Oxidase A (MAOA) and its impact on serotonergic signaling within corticolimbic circuitry.

Report this publication

Statistics

Seen <100 times