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Neural stem cell niche heterogeneity.

Authors
  • Andreotti, Julia P1
  • Silva, Walison N1
  • Costa, Alinne C1
  • Picoli, Caroline C1
  • Bitencourt, Flávia C O1
  • Coimbra-Campos, Leda M C1
  • Resende, Rodrigo R2
  • Magno, Luiz A V3
  • Romano-Silva, Marco A3
  • Mintz, Akiva4
  • Birbrair, Alexander5
  • 1 Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. , (Brazil)
  • 2 Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. , (Brazil)
  • 3 Department of Mental Health, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. , (Brazil)
  • 4 Department of Radiology, Columbia University Medical Center, New York, NY, USA.
  • 5 Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Department of Radiology, Columbia University Medical Center, New York, NY, USA. Electronic address: [email protected] , (Brazil)
Type
Published Article
Journal
Seminars in Cell and Developmental Biology
Publisher
Elsevier
Publication Date
Nov 01, 2019
Volume
95
Pages
42–53
Identifiers
DOI: 10.1016/j.semcdb.2019.01.005
PMID: 30639325
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In mammals, new neurons can be generated from neural stem cells in specific regions of the adult brain. Neural stem cells are characterized by their abilities to differentiate into all neural lineages and to self-renew. The specific microenvironments regulating neural stem cells, commonly referred to as neurogenic niches, comprise multiple cell populations whose precise contributions are under active current exploration. Understanding the cross-talk between neural stem cells and their niche components is essential for the development of therapies against neurological disorders in which neural stem cells function is altered. In this review, we describe and discuss recent studies that identified novel components in the neural stem cell niche. These discoveries bring new concepts to the field. Here, we evaluate these recent advances that change our understanding of the neural stem cell niche heterogeneity and its influence on neural stem cell function. Copyright © 2019. Published by Elsevier Ltd.

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