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Neural crest cells in cardiovascular development.

Authors
Type
Published Article
Journal
Current Topics in Developmental Biology
0070-2153
Publication Date
Volume
111
Pages
183–200
Identifiers
DOI: 10.1016/bs.ctdb.2014.11.006
PMID: 25662261
Source
Medline
Keywords
  • Cardiac Neural Crest
  • Heart Development
  • Outflow Tract
  • Pharyngeal Arch Arteries

Abstract

Cardiac neural crest cells (NCCs) are a transient, migratory cell population exclusive to vertebrate embryos. Ablation, transplantation, and lineage-tracing experiments in chick and mouse have demonstrated their essential role in the remodeling of the initially bilateral and symmetric pharyngeal artery pairs into an aortic arch and for the septation of the cardiac outflow tract into the base of the pulmonary artery and aorta. Accordingly, defective cardiac NCC function is a common cause of congenital birth defects. Here, we review our current understanding of cardiac NCC-mediated vascular remodeling and signaling pathways important for this process. We additionally discuss their contribution to the cardiac valves as well as the still contentious role of cardiac NCCs in the development of the myocardium and conductive system of the heart.

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