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The neural correlates of risk propensity in males and females using resting-state fMRI.

Authors
  • Zhou, Yuan
  • Li, Shu
  • Dunn, John
  • Li, Huandong
  • Qin, Wen
  • Zhu, Maohu
  • Rao, Li-Lin
  • Song, Ming
  • Yu, Chunshui
  • Jiang, Tianzi
Type
Published Article
Journal
Frontiers in Behavioral Neuroscience
Publisher
Frontiers Media SA
Publication Date
Jan 01, 2014
Volume
8
Pages
2–2
Identifiers
DOI: 10.3389/fnbeh.2014.00002
PMID: 24478649
Source
Medline
Keywords
License
Unknown

Abstract

Men are more risk prone than women, but the underlying basis remains unclear. To investigate this question, we developed a trait-like measure of risk propensity which we correlated with resting-state functional connectivity to identify sex differences. Specifically, we used short- and long-range functional connectivity densities to identify associated brain regions and examined their functional connectivities in resting-state functional magnetic resonance imaging (fMRI) data collected from a large sample of healthy young volunteers. We found that men had a higher level of general risk propensity (GRP) than women. At the neural level, although they shared a common neural correlate of GRP in a network centered at the right inferior frontal gyrus, men and women differed in a network centered at the right secondary somatosensory cortex, which included the bilateral dorsal anterior/middle insular cortices and the dorsal anterior cingulate cortex. In addition, men and women differed in a local network centered at the left inferior orbitofrontal cortex. Most of the regions identified by this resting-state fMRI study have been previously implicated in risk processing when people make risky decisions. This study provides a new perspective on the brain-behavioral relationships in risky decision making and contributes to our understanding of sex differences in risk propensity.

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