Affordable Access

deepdyve-link
Publisher Website

The neural correlates of perceived energy levels in older adults with late-life depression.

Authors
  • Lam, Charlene L M1, 2, 3
  • Liu, Ho-Ling4
  • Huang, Chih-Mao5
  • Wai, Yau-Yau6
  • Lee, Shwu-Hua7, 8
  • Yiend, Jenny9
  • Lin, Chemin10
  • Lee, Tatia M C11, 12, 13
  • 1 State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong. , (Hong Kong SAR China)
  • 2 Laboratory of Neuropsychology, The University of Hong Kong, Pokfulam, Hong Kong. , (Hong Kong SAR China)
  • 3 Institute of Clinical Neuropsychology, The University of Hong Kong, Pokfulam, Hong Kong. , (Hong Kong SAR China)
  • 4 Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • 5 College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. , (Taiwan)
  • 6 Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan. , (Taiwan)
  • 7 Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. , (Taiwan)
  • 8 College of Medicine, Chang Gung University, Taoyuan, Taiwan. , (Taiwan)
  • 9 Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • 10 Department of Psychiatry, Chang Gung Memorial Hospital, Keelung City, Taiwan. [email protected] , (Taiwan)
  • 11 State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong. [email protected] , (Hong Kong SAR China)
  • 12 Laboratory of Neuropsychology, The University of Hong Kong, Pokfulam, Hong Kong. [email protected] , (Hong Kong SAR China)
  • 13 Institute of Clinical Neuropsychology, The University of Hong Kong, Pokfulam, Hong Kong. [email protected] , (Hong Kong SAR China)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Oct 01, 2019
Volume
13
Issue
5
Pages
1397–1405
Identifiers
DOI: 10.1007/s11682-018-9940-y
PMID: 30159766
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Late-life depression is common among older adults. Although white-matter abnormality is highly implicated, the extent to which the corticospinal tract is associated with the pathophysiology of late-life depression is unclear. The current study aims to investigate the white-matter structural integrity of the corticospinal tract and determine its cognitive and functional correlates in older adults with late-life depression. Twenty-eight older adults with clinical depression and 23 healthy age-matched older adults participated in the study. The white matter volume and the white matter hyperintensities (WMHs) of the corticospinal tract, as well as the global WMHs, were measured. Psychomotor processing speed, severity of depression, perceived levels of energy and physical functioning were measured to examine the relationships among the correlates in the depressed participants. The right corticospinal tract volume was significantly higher in depressed older adults relative to healthy controls. Moreover, the right corticospinal tract volume was significantly associated with the overall severity of depression and accounted for 17% of its variance. It further attenuated the relationship between the severity of depression and perceived levels of energy. Our findings suggested that higher volume in the right corticospinal tract is implicated in LLD and may relate to lower perceived levels of energy experienced by older adults with depression.

Report this publication

Statistics

Seen <100 times