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Neural Changes Induced by a Speech Motor Treatment in Childhood Apraxia of Speech: A Case Series

Authors
  • Fiori, Simona1
  • Pannek, Kerstin2
  • Podda, Irina3
  • Cipriani, Paola1
  • Lorenzoni, V.4
  • Franchi, Beatrice1
  • Pasquariello, Rosa1
  • Guzzetta, Andrea1, 5
  • Cioni, Giovanni1, 5
  • Chilosi, Anna1
  • 1 Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy
  • 2 CSIRO, Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia
  • 3 Parole al Centro, Studio di Logopedia e Neuropsicomotricità, Genova, Italy
  • 4 Institute of Management, Scuola Superiore Sant’Anna, Pisa, Italy
  • 5 Department of Clinical and Experimental Medicine, University of Pisa, Italy
Type
Published Article
Journal
Journal of Child Neurology
Publisher
SAGE Publications
Publication Date
Jul 28, 2021
Volume
36
Issue
11
Pages
958–967
Identifiers
DOI: 10.1177/08830738211015800
PMID: 34315296
PMCID: PMC8461047
Source
PubMed Central
Keywords
Disciplines
  • Original Articles
License
Unknown

Abstract

We report a case series of children with childhood apraxia of speech, by describing behavioral and white matter microstructural changes following 2 different treatment approaches. Five children with childhood apraxia of speech were assigned to a motor speech treatment (PROMPT) and 5 to a language, nonspeech oral motor treatment. Speech assessment and brain MRI were performed pre- and post-treatment. The ventral (tongue/larynx) and dorsal (lips) corticobulbar tracts were reconstructed in each subject. Mean fractional anisotropy and mean diffusivity were extracted. The hand corticospinal tract was assessed as a control pathway. In both groups speech improvements paralleled changes in the left ventral corticobulbar tract fractional anisotropy. The PROMPT treated group also showed fractional anisotropy increase and mean diffusivity decrease in the left dorsal corticobulbar tract. No changes were detected in the hand tract. Our results may provide preliminary support to the possible neurobiologic effect of a multimodal speech motor treatment in childhood apraxia of speech.

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