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Neural cell adhesion molecule expression, neuroendocrine differentiation and prognosis in lung carcinoma.

Authors
  • Kibbelaar, R E
  • Moolenaar, K E
  • Michalides, R J
  • Van Bodegom, P C
  • Vanderschueren, R G
  • Wagenaar, S S
  • Dingemans, K P
  • Bitter-Suermann, D
  • Dalesio, O
  • Van Zandwijk, N
Type
Published Article
Journal
European Journal of Cancer
Publisher
Elsevier
Publication Date
Jan 01, 1991
Volume
27
Issue
4
Pages
431–435
Identifiers
PMID: 1851619
Source
Medline
License
Unknown

Abstract

We investigated the expression of the neural cell adhesion molecule (NCAM) in a series of surgically resected lung carcinomas of various histological subtypes by means of a panel of monoclonal antibodies recognising different N-CAM epitopes. In a subgroup of 56 tumours, the results of immunostaining with MAb 123C3--the antibody studied most extensively in our material--were compared to the ultrastructure, and in 231 radically resected non-small cell carcinomas, with histological tumour type and with clinical follow-up data. N-CAM expression was not limited to neuroendocrine tumours, as assessed ultrastructurally. Non-small cell lung carcinomas positive for MAb 123C3 showed post-operative overall and disease-free survival times significantly shorter than 123C3-negative non-small cell carcinomas.

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