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Neural and Behavioral Effects of an Adaptive Online Verbal Working Memory Training in Healthy Middle-Aged Adults

Authors
  • Emch, Mónica1, 2, 3
  • Ripp, Isabelle2, 3, 4
  • Wu, Qiong1, 2
  • Yakushev, Igor2, 3, 4
  • Koch, Kathrin1, 2, 3
  • 1 Department of Neuroradiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich , (Germany)
  • 2 TUM-Neuroimaging Center, Technical University of Munich, Munich , (Germany)
  • 3 Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität, Martinsried , (Germany)
  • 4 Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich , (Germany)
Type
Published Article
Journal
Frontiers in Aging Neuroscience
Publisher
Frontiers Media SA
Publication Date
Nov 01, 2019
Volume
11
Identifiers
DOI: 10.3389/fnagi.2019.00300
Source
Frontiers
Keywords
Disciplines
  • Neuroscience
  • Original Research
License
Green

Abstract

Neural correlates of working memory (WM) training remain a matter of debate, especially in older adults. We used functional magnetic resonance imaging (fMRI) together with an n-back task to measure brain plasticity in healthy middle-aged adults following an 8-week adaptive online verbal WM training. Participants performed 32 sessions of this training on their personal computers. In addition, we assessed direct effects of the training by applying a verbal WM task before and after the training. Participants (mean age 55.85 ± 4.24 years) were pseudo-randomly assigned to the experimental group (n = 30) or an active control group (n = 27). Training resulted in an activity decrease in regions known to be involved in verbal WM (i.e., fronto-parieto-cerebellar circuitry and subcortical regions), indicating that the brain became potentially more efficient after the training. These activation decreases were associated with a significant performance improvement in the n-back task inside the scanner reflecting considerable practice effects. In addition, there were training-associated direct effects in the additional, external verbal WM task (i.e., HAWIE-R digit span forward task), and indicating that the training generally improved performance in this cognitive domain. These results led us to conclude that even at advanced age cognitive training can improve WM capacity and increase neural efficiency in specific regions or networks.

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