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A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine.

Authors
  • Turanli, Beste1
  • Karagoz, Kubra2
  • Gulfidan, Gizem3
  • Sinha, Raghu4
  • Mardinoglu, Adil5
  • Arga, Kazim Yalcin3
  • 1 Department of Bioengineering, Faculty of Engineering and Natural Sciences, Istanbul Medeniyet University, Istanbul. Turkey. , (Turkey)
  • 2 Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey. United States. , (Jersey)
  • 3 Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul. Turkey. , (Turkey)
  • 4 Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania. United States. , (United States)
  • 5 Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm. Sweden. , (Sweden)
Type
Published Article
Journal
Current pharmaceutical design
Publication Date
Nov 05, 2018
Identifiers
DOI: 10.2174/1381612824666181106095959
PMID: 30398107
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A complex framework of interacting partners including genetic, proteomic, and metabolic networks that cooperate to mediate specific functional phenotypes drives human biological processes. Recent technological and analytical advances in "omic" sciences allow the identification and elucidation of reprogramming biological functions in response to perturbations in cells and tissues. To understand such a complex system, biological networks are generated to reduce the complexity into relatively simple models, and the integration of these molecular networks from different perspectives is implemented for a holistic interpretation of the entire system. Ultimately, network-based methods will effectively facilitate the development and improvement of precision medicine by directing therapies based on the underlying biology of a given patient's disease. The goal of precision medicine is to identify novel therapeutic strategies that can be optimized for each disease type or each patient based on the underlying genetic, environmental, and lifestyle factors. Pharmaco-omics analyses based on an integration of pharmacology and various "omics" data types can be employed to develop effective treatment strategies using particular drugs and doses that are tailored to each individual. In the current review, we first present the core elements of network-based systems biology in the context of pharmaco-omics followed by integration of multi-omics data using various biological networks. Next, we provide an opening into precise medicine and drug targeting based on network approaches. Lastly, we review the current significant efforts as well as the accomplishments and limitations in precise drug targeting with the utility of network-based guided drug discovery methods for effective treatment of breast cancer. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]

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